Fri Aug 05 2022

59 articles - From Friday Jul 29 2022 to Friday Aug 05 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Ann Intern Med

Preventing Obesity in Midlife Women: A Systematic Review for the Women's Preventive Services Initiative.

Counseling interventions to prevent weight gain in women during midlife may result in modest differences in weight change without causing important harms. More research is needed to determine optimal content, frequency, length, and number of sessions required and should include additional patient populations. Primary funding source Health Resources and Services Administration.

Pubmed   Journal   ReadQx 

Lancet

Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis.

The total randomised evidence to date suggests that JAK inhibitors (chiefly baricitinib) reduce mortality in patients hospitalised for COVID-19 by about one-fifth. Funding UK Research and Innovation (Medical Research Council) and National Institute of Health Research.

Pubmed   Journal   ReadQx   PMC


Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Intern Med

Evaluating the Performance of Centers for Disease Control and Prevention COVID-19 Community Levels as Leading Indicators of COVID-19 Mortality.

Designing metrics for public health decision making involves tradeoffs between identifying early signals for action and avoiding undue restrictions when risks are modest. Explicit frameworks for evaluating surveillance metrics can improve transparency and decision support. Primary funding source Council of State and Territorial Epidemiologists.

Pubmed   Journal   ReadQx 

In diabetes, some statins reduce non-HDL-C better than others vs. placebo.

2022; 376:e067731. 35331984.

Pubmed   Journal   ReadQx 

In drug-refractory IBS, group CBT with interoceptive exposure improved symptoms and QoL at 13 wk.

2022; 117:668-77. 35103022.

Pubmed   Journal   ReadQx 

In HF, SGLT2 inhibitors reduce HF hospitalizations at up to 2 y.

2022; 175:851-61. 35404670.

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In IBS, a smartphone application for self-managing a FODMAP-lowering diet vs. otilonium bromide reduced symptoms at 8 wk.

[Epub ahead of print]. 35483886.

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In older adults, iron dextran and ferumoxytol each had higher anaphylaxis risk at =1 d than iron sucrose.

2022; 175:656-64. 35344378.

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In persons at risk for poor vaccination response or COVID-19 exposure, tixagevimab + cilgavimab reduced COVID-19.

2022; 386:2188-200. 35443106.

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mRNA COVID-19 vaccines were linked to myocarditis at 28 d (0.15 to 10 excess events/100 000 vaccinated persons).

2022; 7:600-12. 35442390.

Pubmed   Journal   ReadQx 

Patients surviving COVID-19 had increased risk for incident diabetes vs. persons without COVID-19.

2022; 10:311-21. 35325624.

Pubmed   Journal   ReadQx 

Preventing Obesity in Midlife Women: A Recommendation From the Women's Preventive Services Initiative.

Recommendation The WPSI recommends counseling midlife women aged 40 to 60 years with normal or overweight BMI (18.5 to 29.9 kg/m 2 ) to maintain weight or limit weight gain to prevent obesity. Counseling may include individualized discussion of healthy eating and physical activity.

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Recommendations for use of ezetimibe and/or PCSK9 inhibitors in patients with elevated LDL-C.

2022; 377:e069066. 35508320.

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Reduced dietary sodium did not reduce clinical events in heart failure.

2022; 399:1391-400. 35381194.

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Lancet

Endoscopic sleeve gastroplasty for treatment of class 1 and 2 obesity (MERIT): a prospective, multicentre, randomised trial.

gov, NCT03406975. Funding Apollo Endosurgery, Mayo Clinic.

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Upadacitinib for the treatment of active non-radiographic axial spondyloarthritis (SELECT-AXIS 2): a randomised, double-blind, placebo-controlled, phase 3 trial.

These findings support the potential of upadacitinib as a new therapeutic option in patients with active non-radiographic axial spondyloarthritis. Funding AbbVie.

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N Engl J Med

Low-Dose Subcutaneous or Intravenous Monoclonal Antibody to Prevent Malaria.

In this small trial, L9LS administered intravenously or subcutaneously protected recipients against malaria after controlled infection, without evident safety concerns. (Funded by the National Institute of Allergy and Infectious Diseases; VRC 614 ClinicalTrials.gov number, NCT05019729.).

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Trial of Cinpanemab in Early Parkinson's Disease.

In participants with early Parkinson's disease, the effects of cinpanemab on clinical measures of disease progression and changes in DaT-SPECT imaging did not differ from those of placebo over a 52-week period. (Funded by Biogen; SPARK ClinicalTrials.gov number, NCT03318523.).

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Trial of Prasinezumab in Early-Stage Parkinson's Disease.

Prasinezumab therapy had no meaningful effect on global or imaging measures of Parkinson's disease progression as compared with placebo and was associated with infusion reactions. (Funded by F. Hoffmann-La Roche and Prothena Biosciences; PASADENA ClinicalTrials.gov number, NCT03100149.).

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Lancet

Monkeypox: a global wake-up call.

Pubmed   Journal   ReadQx 

N Engl J Med

Audio Interview: Updated Covid-19 Vaccines and a Look at Monkeypox.

Pubmed   Journal   ReadQx 

Monoclonal Antibodies - A Different Approach to Combat Malaria.

Pubmed   Journal   ReadQx 

Monoclonal Antibodies for Malaria.

Pubmed   Journal   ReadQx 

Monoclonal Antibody Therapy in Parkinson's Disease - The End?

Pubmed   Journal   ReadQx 

Spina Bifida.

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies

N Engl J Med

A Zoonotic Henipavirus in Febrile Patients in China.

Pubmed   Journal   ReadQx 

Childhood Risk Factors and Adult Cardiovascular Events.

Pubmed   Journal   ReadQx 

Childhood Risk Factors and Adult Cardiovascular Events.

Pubmed   Journal   ReadQx 

Childhood Risk Factors and Adult Cardiovascular Events.

Pubmed   Journal   ReadQx 

Childhood Risk Factors and Adult Cardiovascular Events. Reply.

Pubmed   Journal   ReadQx 

Gliflozins in the Management of Cardiovascular Disease.

Pubmed   Journal   ReadQx 

Gliflozins in the Management of Cardiovascular Disease.

Pubmed   Journal   ReadQx 

Nonspecific Low Back Pain.

Pubmed   Journal   ReadQx 

Nonspecific Low Back Pain.

Pubmed   Journal   ReadQx 

Nonspecific Low Back Pain. Reply.

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Oncogene Up-Regulation after Hypomethylating Therapy.

Pubmed   Journal   ReadQx 

Oncogene Up-Regulation after Hypomethylating Therapy. Reply.

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Understanding REM Sleep Behavior Disorder in Parkinson's Disease.

Pubmed   Journal   ReadQx 


Others

all remaining publications eg case reports, images of the month, etc…

Ann Intern Med

Annals On Call - Opioid Use Disorder.

Pubmed   Journal   ReadQx 

Annals Video Summary - Preventing Obesity in Midlife Women.

Pubmed   Journal   ReadQx 

Summary for Patients: Preventing Obesity in Midlife Women.

Pubmed   Journal   ReadQx 

Lancet

Baricitinib in COVID-19: a coming-of-age from artificial intelligence to reducing mortality.

Pubmed   Journal   ReadQx   PMC

Calvarium indentations in multiple myeloma and CAR T-cell therapy.

Pubmed   Journal   ReadQx 

Cathie Sudlow: devoted to data.

Pubmed   Journal   ReadQx 

ESG should be judged on its own merits.

Pubmed   Journal   ReadQx 

How medical education holds back health equity.

Pubmed   Journal   ReadQx 

Lower taxes or greater health equity.

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Measuring sex, gender, and sexual orientation: one step to health equity.

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Monkeypox PHEIC decision hoped to spur the world to act.

Pubmed   Journal   ReadQx 

New Dutch regulations to alleviate drug shortages.

Pubmed   Journal   ReadQx 

Upadacitinib for the treatment of active non-radiographic axial spondyloarthritis.

Pubmed   Journal   ReadQx 

Urvashi Vaid.

Pubmed   Journal   ReadQx 

Violence against health workers rises during COVID-19.

Pubmed   Journal   ReadQx   PMC

N Engl J Med

Code Words.

Pubmed   Journal   ReadQx 

Diagnostic Aspirations.

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Japanese Spotted Fever.

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Left Atrial Thrombus.

Pubmed   Journal   ReadQx 

More Than a Little Unsteady.

Pubmed   Journal   ReadQx 

Tecovirimat and the Treatment of Monkeypox - Past, Present, and Future Considerations.

Pubmed   Journal   ReadQx